Our paper “Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration disrupting daytime locomotion” that reveals the impact of macrophage inflammation on spontaneous locomotor change is published early as a preprint on BioRxiv. Check it out here: https://doi.org/10.1101/2021.10.27.466033. This was made possible by a large team effort over a long timeline to accomplish such an immense study that spans multiple disciplines.
Our study provides detailed characterizations of intestinal macrophages and demonstrate diverse populations in zebrafish for further investigations. Read here.
Check it out here: https://elifesciences.org/articles/58191
Dr. Shiau awarded a 5-year Outstanding Early-Stage Investigator MIRA grant from NIGMS! The MIRA mechanism provides flexibility for NIGMS-supported investigators to pursue innovative and important research directions. The Shiau Lab will use this award to study the genetic and metabolic regulation of macrophage activation in vivo using zebrafish and other systems. This has implications for the design of macrophage-targeted technologies for controlling inflammatory processes and addressing health challenges related to immune dysregulation.