Sneak peek on a really cool macrophage-brain-behavior study out on preprint!

Our paper “Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration disrupting daytime locomotion” that reveals the impact of macrophage inflammation on spontaneous locomotor change is published early as a preprint on BioRxiv. Check it out here: https://doi.org/10.1101/2021.10.27.466033. This was made possible by a large team effort over a long timeline to accomplish such an immense study that spans multiple disciplines.

Check out our newest paper in eLife!

Check it out here: https://elifesciences.org/articles/58191


Microinjection of traceable LPS into the brain leads to drainage of LPS molecules into circulation, and causes active infiltration of peripheral macrophages into the liver. (a) Schematic. (b) Whole-body in vivo imaging analysis. Dotted line demarcates the liver.
In vivo time-lapse imaging tracking macrophages (green) infiltrating the liver (red) in real time in the 4 dpf zebrafish larvae. Left, merged channels; Right, macrophages only (green channel).
Coordination and intimate contacts between macrophages and neutrophils are prevalent around the liver in the normal living zebrafish. Video shows time-lapse confocal imaging of macrophages (green) and neutrophils (red).

Dr. Celia Shiau awarded 5-year NIH grant

Dr. Shiau awarded a 5-year Outstanding Early-Stage Investigator MIRA grant from NIGMS!  The MIRA mechanism provides flexibility for NIGMS-supported investigators to pursue innovative and important research directions.  The Shiau Lab will use this award to study the genetic and metabolic regulation of macrophage activation in vivo using zebrafish and other systems.  This has implications for the design of macrophage-targeted technologies for controlling inflammatory processes and addressing health challenges related to immune dysregulation.